N-Biotinyl-6-aminohexanoic acid (N-(+)-Biotinyl-6-aminohexanoic acid) is utilized for N-terminal biotinylation.

The SERS (surface-enhanced Raman scattering) of cyclohexyl isocyanide that silver nanoparticles modified with N-Biotinyl-6-aminohexanoic acid and cyclohexyl isocyanide can be anchored on a separate biotinylated substrate via the avidin-biotin interaction[1].Synthesis of p-nitrophenyl N-acetyllactosaminide with β-D-galactosidase, chemical reduction of the p-nitrophenyl group, and sialylation with sialyltransferase.?The p-aminophenyl glycosides are successfully biotin-labeled through the coupling with N-Biotinyl-6-aminohexanoic acid to afford biotinylated oligosaccharides with an aminohexanosyl group and phenyl group as the spacers between the biotin and glycan.?The biotin-labeled sugars were shown to be useful for immobilization and assay of the carbohydrate-lectin interactions by an optical biosensor based on surface plasmon resonance[2].